Over 50 clinical trials, including long-term and high-dosage trials in different groups, have proven the efficacy and safety of plant sterols in Flora ProActiv.
A 2014 meta-analysis of randomised controlled studies explored results from 124 human studies.35 The study found that plant sterols significantly reduce LDL-cholesterol concentrations in a dose-dependent manner (P <0.001).
You can find details of the clinical data here.
Plant sterols and stanols have a similar dose-dependent cholesterol-lowering effect, which continues to increase to an average effect of 12% LDL-concentration reduction for intakes of up to approximately 3g/day.35